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Co-infection with Influenza and COVID-19, commonly known as "Flurona," has been confirmed in approximately 1,200 cases nationwide in Japan (as of November) and poses a severity risk incomparable to single-pathogen infections. Latest national data (MHLW, NIID) reveals that Flurona elevates the risk of hospitalization by 4−6 times and the mortality risk by up to 15 times. This article thoroughly compares the real danger of co-infection and the decisive differences in symptoms, based on the predominant strains in 2025. It is crucial to understand the worst-case scenario—the simultaneous onset of "Influenza's rapid high fever" and "COVID's breathlessness and persistent cough"—and to take action immediately upon symptom onset.

This summary provides the actual incidence rates and comprehensive management strategies for influenza vaccine side effects, based on the latest reports from the Ministry of Health, Labour and Welfare, PMDA data, and the Japanese Association for Infectious Diseases summary, covering the period from October 2025 to the present.

Based on 2024-2025 seasonal data in Japan and the latest guidelines (Japanese Association for Infectious Diseases, Japan Society of Obstetrics and Gynecology, and MHLW 2025 Revision), this summary focuses on the severe illness risks and specific countermeasures for the elderly (aged 65 and over) and pregnant women.

The treatment for influenza (Type A and B) is primarily categorized into two classes of drugs: neuraminidase inhibitors (e.g., Tamiflu, Relenza) and endonuclease inhibitors (Xofluza). Based on the guidelines from the Japanese Association for Infectious Diseases and the Ministry of Health, Labour and Welfare, early administration within 48 hours of onset is recommended, and is expected to shorten the duration of symptoms by 1 to 2 days. For high-risk patients (elderly, those with underlying conditions, pregnant women), emphasis is also placed on the effect of preventing severe illness. The focus of this summary will be on Tamiflu (Oseltamivir), Xofluza (Baloxavir), and Nasal Sprays (Relenza).

The influenza vaccine is one of the safest vaccines in the world. Side effects are almost always mild: "Risk of NOT being vaccinated" > "Risk of side effects."

Below is the ranking of average monthly rent by prefecture, based on the Ministry of Internal Affairs and Communications' "Housing and Land Survey" (2018 data). This data reflects the average monthly rent for rental housing nationwide (primarily private rental properties), with the national average being approximately ¥61,367. The data is relatively comprehensive and reliable, serving as the basis for this ranking. While recent trends (around 2023-2024) show a slight increase due to inflation and regional demand, the relative ranking has not significantly changed.(Source: Ministry of Internal Affairs and Communications, Housing and Land Survey)

A comparison of the latest mortality rankings in Japan and the world reveals a clear difference in the "structure of death" between the two. In Japan, where cancer (malignant neoplasms) has been the number one cause for 43 consecutive years (according to the 2023 statistics from the Ministry of Health, Labour and Welfare), a "longevity-type" mortality structure is evident, notably with senility (old age) surging to the 3rd rank. In contrast, the global ranking, based on WHO and GBD 2023 estimates, is dominated by a "lifestyle disease and infectious disease-type" structure, where Ischemic Heart Disease is the overwhelming number one, and lower respiratory infections and diabetes occupy high ranks. However, the causes of sudden death, such as heart attacks, are nearly identical between Japan and the US, with the post-event survival rate being the major difference.

The latest data from the World Health Organization (WHO) and the Global Burden of Disease (GBD) Study for 2023 highlights the world's most critical public health challenges. Of the world's total estimated deaths of over 60 million people, Ischemic Heart Disease (such as myocardial infarction) overwhelmingly ranks first with about 9 million deaths. Together with stroke, these two account for roughly one-quarter of total global deaths. Notably, Non-Communicable Diseases (NCDs) occupy the top seven spots, with their proportion increasing yearly due to aging populations and lifestyle changes. Furthermore, "Sudden Death," which unexpectedly strikes approximately 6-7 million people annually, is caused by cardiovascular disease in over 80% of cases.

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