【Types of Cerebral Infarction】The Critical Differences Between Lacunar, Atherothrombotic, and Cardioembolic Stroke, and the 3 Major Risk Factors

Cerebral infarction is not a single disease. It is broadly categorized into three types based on the mechanism of onset: “Lacunar Infarction,” “Atherothrombotic Infarction,” and “Cardioembolic Infarction.” Each type has different causes, treatments, and secondary prevention strategies.

Causation and Types of Cerebral Infarction

Type (Frequency)Formal NameMechanism of OnsetMain Causes / Risk FactorsCommon Age / Characteristics
1. Lacunar Infarction(≈25−35%)Small Vessel OcclusionComplete blockage of the small, deep perforating arteries (0.2−1.5 mm in diameter) within the brain.* Chronic High Blood Pressure * Diabetes * Smoking * AgingMost common in 50s−70s. Often presents with classic symptoms like “pure motor hemiparesis,” “pure sensory stroke,” or “sensorimotor stroke.”
2. Atherothrombotic Infarction(≈25−35%)Large Vessel AtherosclerosisAtherosclerotic plaque builds up in the wall of large arteries (e.g., carotid or basilar artery), leading to: ① Direct blockage, or ② Plaque rupture, causing fragments to block smaller vessels.* All risk factors for Atherosclerosis: High BP, Diabetes, Dyslipidemia, Smoking, Obesity, Aging * Carotid Artery Stenosisis a well-known risk.Most common after 60s. Often results in large infarcts and tends to be severe.
3. Cardioembolic Infarction(≈25−35%)Embolism of Cardiac OriginA blood clot forms within the heart (especially the left atrium), dislodges, and travels to block a cerebral artery. The location of the blockage is unpredictable.Atrial Fibrillation (AFib) * Post-Myocardial Infarction * Valvular Heart Disease * Heart Failure, Infectious EndocarditisWide age range. Characterized by sudden onset, high severity, and high recurrence rate.
4. Other / Undetermined(≈5−10%)* Arterial dissection * Vasculitis * Blood coagulation disorders * Paradoxical embolism (clot bypasses lungs to brain)Causes are often hidden here, particularly in younger individuals. Can occur in 20s−40s.

Comparison of Types (At a Glance)

ItemLacunar InfarctionAtherothrombotic InfarctionCardioembolic Infarction
Onset PatternOften gradualStepwise deterioration (hours to days)Sudden, maximal at onset
Impairment of ConsciousnessRarelySometimesCommon
Vessel BlockedSmall perforating arteriesLarge arteries + distal vesselsMedium to large arteries (unpredictable)
Secondary Prevention DrugAntiplatelet drugAntiplatelet drug + StatinAnticoagulant (Warfarin or DOAC)
Most Crucial Risk FactorHigh Blood PressureAtherosclerosisAtrial Fibrillation
Imaging FindingsSmall infarct (<1.5 cm)Large or multiple infarctsScattered across multiple vascular territories

Causes of Stroke in Young People (Under Age 50) – Recent Data Ranking

  1. Cardioembolic Stroke (Atrial Fibrillation, Patent Foramen Ovale)
  2. Arterial Dissection (Carotid or Vertebral Artery)
  3. Hypercoagulable states (Blood coagulation disorders)
  4. Vasculitis / Collagen Vascular Diseases Lacunar and Atherothrombotic are less common.

Summary

  • Individuals with chronic High Blood Pressure → Lacunar Infarction
  • Individuals with multiple lifestyle diseases → Atherothrombotic Infarction
  • Individuals with Atrial Fibrillation → Cardioembolic Infarction