Influenza PCR Test: Complete Guide [2025 Latest Edition] When is the 99.9% Accurate Genetic Test Necessary?

In the diagnosis of influenza, the test that boasts the highest accuracy is the PCR test (Real-Time RT-PCR). While the common rapid antigen test determines if a virus is currently in the body, the PCR test directly detects the virus’s genetic material, making its accuracy over 99.9%.

As of 2025, the PCR test is utilized as the “ultimate weapon” for cases where the result from a conventional rapid test is unclear, or for patients with a high risk of severe illness (such as the elderly and those with underlying health conditions).

Details of the Influenza PCR Test (2025 Japan)

ItemDetails
Formal NameReal-Time RT-PCR (Reverse Transcription + Gene Amplification Test)
What it DetectsInfluenza Type A and B (Plus subtyping is possible: H1N1pdm, H3N2, Victoria, Yamagata lineages, etc.)
Viruses Detected SimultaneouslyAlmost all mainstream kits for the 2024-2025 season test for Influenza + COVID-19 + RSV(3–4 items simultaneously).
Accuracy (Sensitivity/Specificity)Sensitivity 99.5–100%, Specificity 100% (False negatives and false positives are virtually zero).
Time RequiredFastest equipment: 40–60 minutes / General hospital: 2–6 hours / Outsourced test: Morning of the next day
Specimen Collection MethodNasopharyngeal swab (Swab deep into the nose) Note: Saliva PCR is not covered by insurance for influenza as of 2025.
Cost Estimate (30% Co-pay)¥1,800–¥3,500 (Varies based on the number of simultaneous tests)
Main Cases Covered by InsuranceAges 65+ / Presence of underlying conditions / Pregnant women / High severity despite a negative rapid test / Need for hospitalization / Cluster outbreaks in facilities/schools / When deemed medically necessary by a doctor

Main Locations for Receiving a PCR Test (As of 2025)

LocationTime to ResultKey Features
Large General Hospitals/University Hospitals1–3 hoursFastest. Available even at night.
Fever Clinics (PCR dedicated)1–4 hoursOften appointment-only.
Local PCR CentersSame day to next dayFree or low-cost (depending on municipality).
Regular ClinicsNext day resultSlower due to outsourcing the test.

Typical Patterns Where a Doctor Decides on “PCR”

  • High fever and difficulty breathing persist after two negative rapid tests.
  • High risk of severe illness, such as the elderly, diabetics, or those with heart disease.
  • The entire family is positive, but the patient is rapid-test negative.
  • Hospitalization is required (especially if a Tamiflu-resistant strain is suspected).
  • When a school or facility requires knowledge of the “exact strain type.”

Summary

  • Normal people get a rapid test first → PCR only if something is highly suspicious.
  • PCR is the “ultimate weapon that provides a nearly 100% correct answer.”
  • It is not used unless a doctor deems it necessary because it takes time and is more expensive.

At-Home Testing Kit Ranking (Combined COVID-19 and Influenza)

Here is the English translation of the ranking table for at-home diagnostic kits that test for both COVID-19 and Influenza A/B:

RankProduct Name (Manufacturer)Targets DetectedSensitivity (Detection Rate) (Estimate: 12-48h Post-Onset)Result TimeApproximate Price (Per Test)Suitability for Pregnant Women / ChildrenKey Features & Availability
1Panbio COVID-19/Flu A&B COVID + Flu A/BCOVID: Approx. 90%Flu: Approx. 85%15 mins¥1,980 – ¥2,480◎ (Shallow Nasal Swab)
2クイックナビ-Flu+COVIDSame (COVID + Flu A/B)COVID: 88%Flu: 80–85%15–20 mins¥1,780 – ¥2,200◎ (Designed for children’s use)
3KBMラインチェック nCoV/Flu Same (COVID + Flu A/B)COVID: 85%Flu: Approx. 80%15 mins¥1,480 – ¥1,980
4イージードック Flu&COVID-19 Same (COVID + Flu A/B)COVID: 87%Flu: 82%15 mins¥2,200 – ¥2,600◎ (Many cases of use by pregnant women)